Abstract |
Erythrocyte transfusion can impair detection of sickle-cell disease, galactosemia, or biotinidase deficiency with newborn screening. We report on 4 infants with SCD in whom delayed diagnosis was associated with neonatal transfusion. In 2 cases, the initial newborn screening showed no hemoglobin S. In no case was the recommended screening >/=120 days from the last transfusion obtained. Two children had significant SCD-related morbidity before diagnosis.
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Authors | W Reed, P A Lane, F Lorey, J Bojanowski, M Glass, R R Louie, B H Lubin, E P Vichinsky |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 136
Issue 2
Pg. 248-50
(Feb 2000)
ISSN: 0022-3476 [Print] United States |
PMID | 10657834
(Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Anemia, Neonatal
(therapy)
- Anemia, Sickle Cell
(diagnosis)
- Blood Group Incompatibility
(therapy)
- Child, Preschool
- Erythrocyte Transfusion
- Humans
- Infant
- Infant, Newborn
- Neonatal Screening
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