HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Sickle-cell disease not identified by newborn screening because of prior transfusion.

Abstract
Erythrocyte transfusion can impair detection of sickle-cell disease, galactosemia, or biotinidase deficiency with newborn screening. We report on 4 infants with SCD in whom delayed diagnosis was associated with neonatal transfusion. In 2 cases, the initial newborn screening showed no hemoglobin S. In no case was the recommended screening >/=120 days from the last transfusion obtained. Two children had significant SCD-related morbidity before diagnosis.
AuthorsW Reed, P A Lane, F Lorey, J Bojanowski, M Glass, R R Louie, B H Lubin, E P Vichinsky
JournalThe Journal of pediatrics (J Pediatr) Vol. 136 Issue 2 Pg. 248-50 (Feb 2000) ISSN: 0022-3476 [Print] United States
PMID10657834 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Topics
  • Anemia, Neonatal (therapy)
  • Anemia, Sickle Cell (diagnosis)
  • Blood Group Incompatibility (therapy)
  • Child, Preschool
  • Erythrocyte Transfusion
  • Humans
  • Infant
  • Infant, Newborn
  • Neonatal Screening

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: