Abstract |
Landau-Kleffner syndrome (LKS) is a rare childhood disorder characterized by acquired aphasia with seizures and electroencephalogram (EEG) abnormalities. Tc-99m-HMPAO SPECT was performed in three right handed children with LKS. A relative decrease in perfusion was found in the left temporal cortex of all three patients and also in the left frontoparietal cortex of one patient with hyperkinetic behavior. Degree of regional cerebral perfusion impairment did not correlate with the severity of clinical and EEG abnormalities. Asymmetrical temporoparietal perfusion appears characteristic of LKS. SPECT findings in LKS were evaluated as useful in elucidating the pathogenic features of the disorder in the brain.
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Authors | E Sayit, E Dirik, H Durak, N Uzuner, O Anal, N T Cevik |
Journal | Annals of nuclear medicine
(Ann Nucl Med)
Vol. 13
Issue 6
Pg. 415-8
(Dec 1999)
ISSN: 0914-7187 [Print] Japan |
PMID | 10656276
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anticonvulsants
- Radiopharmaceuticals
- Carbamazepine
- Technetium Tc 99m Exametazime
- Clonazepam
- Valproic Acid
- Dexamethasone
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Topics |
- Anticonvulsants
(therapeutic use)
- Brain
(diagnostic imaging, physiopathology)
- Carbamazepine
(therapeutic use)
- Cerebrovascular Circulation
- Child, Preschool
- Clonazepam
(therapeutic use)
- Dexamethasone
(therapeutic use)
- Electroencephalography
- Evoked Potentials, Auditory, Brain Stem
- Frontal Lobe
(blood supply)
- Humans
- Landau-Kleffner Syndrome
(diagnostic imaging, drug therapy, physiopathology)
- Male
- Parietal Lobe
(blood supply)
- Radiopharmaceuticals
(pharmacokinetics)
- Technetium Tc 99m Exametazime
(pharmacokinetics)
- Temporal Lobe
(blood supply)
- Tomography, Emission-Computed, Single-Photon
- Valproic Acid
(therapeutic use)
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