Complement receptor type 3 plays an important role in development of protective immunity to primary and secondary Corynebacterium pseudotuberculosis infection in mice.

Abstract

The present study was performed to investigate the role of CR3, the type 3 complement receptor, in host defense against primary and secondary Corynebacterium (C.) pseudotuberculosis infection in mice. Treatment of mice with 5C6, an anti-CR3 monoclonal antibody (mAb), resulted in unrestricted multiplication of bacteria in the organs and dramatically increased mortalities of the infected mice. Histological examinations showed the inflammation, degeneration and necrosis of organs and revealed that the infection-enhancing effect of 5C6 mAb was associated with the failure of mice to focus mononuclear phagocytes at sites of bacterial multiplication. These results suggest that CR3 plays an important role in host defense against primary as well as secondary C. pseudotuberculosis infection in mice.

• Authors: D T Lan, S Makino, T Shirahata, M Yamada, A Nakane
• Journal: Microbiology and immunology (Microbiol Immunol) Vol. 43 Issue 12 Pg. 1103-6 ( 1999) ISSN: 0385-5600 [Print] Australia
• PMID: 10656178 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• Macrophage-1 Antigen
• Tumor Necrosis Factor-alpha
• Interferon-gamma

Topics

• Animals
• Antibodies, Monoclonal (administration & dosage, pharmacology)
• Colony Count, Microbial
• Corynebacterium Infections (immunology, metabolism)
• Corynebacterium pseudotuberculosis (immunology)
• Enzyme-Linked Immunosorbent Assay
• Injections, Intraperitoneal
• Interferon-gamma (biosynthesis)
• Liver (microbiology, pathology)
• Macrophage-1 Antigen (immunology)
• Mice
• Mice, Inbred ICR
• Spleen (microbiology, pathology)
• Tumor Necrosis Factor-alpha (biosynthesis)