Abstract | BACKGROUND: METHODS: RESULTS: Pro-inflammatory and anti-inflammatory mediators were measured. Peak concentrations of proinflammatory interleukin-6, interleukin-8, were significantly lower in 15 patients undergoing Drew-Anderson Technique compared with the concentrations measured in 15 patients treated with standard cardiopulmonary bypass technique. Differences in patient recovery were analyzed with respect to time of intubation, blood loss, intrapulmonary shunting, oxygenation, and respiratory index. In patients undergoing uncomplicated coronary artery bypass grafting procedures bilateral extracorporeal circulation using the patients' own lung as oxygenator provided significant biochemical and clinical benefit in comparison to the standard cardiopulmonary bypass procedure. CONCLUSIONS: This prospective randomized clinical study has demonstrated that exclusion of an artificial oxygenator from cardiopulmonary bypass circuit significantly decreases the activation of inflammatory reaction, and that interventions that attenuate this response may result in more favorable clinical outcome.
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Authors | J A Richter, H Meisner, P Tassani, A Barankay, W Dietrich, S L Braun |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 69
Issue 1
Pg. 77-83
(Jan 2000)
ISSN: 0003-4975 [Print] Netherlands |
PMID | 10654491
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Inflammation Mediators
- Interleukin-6
- Interleukin-8
- Oxygen
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Topics |
- Aged
- Analysis of Variance
- Blood Loss, Surgical
- Cardiopulmonary Bypass
(adverse effects)
- Chi-Square Distribution
- Coronary Artery Bypass
- Elective Surgical Procedures
- Extracorporeal Circulation
(methods)
- Humans
- Inflammation Mediators
(blood)
- Interleukin-6
(blood)
- Interleukin-8
(blood)
- Intubation, Intratracheal
- Lung
(physiology)
- Middle Aged
- Oxygen
(blood)
- Prospective Studies
- Pulmonary Gas Exchange
(physiology)
- Respiration
- Respiratory Physiological Phenomena
- Systemic Inflammatory Response Syndrome
(prevention & control)
- Time Factors
- Treatment Outcome
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