Abstract | BACKGROUND: METHOD: RESULTS: Twelve months after transplantation, the mean (+/- SEM) BMD of the lumbar vertebrae in patients who received placebo had decreased 6.4% (P < 0.05). In contrast, patients who received pamidronate experienced no significant reduction of BMD at the lumbar vertebrae. At the femoral neck, placebo-treated patients showed a reduction of BMD of 9% (P < 0.005), whereas there was no significant change in the pamidronate treated group. The two study groups had similar patient profiles, serum parathyroid hormone (PTH) and aluminium concentrations. After transplantation, comparable falls in the serum creatinine and PTH concentration were found in the two groups. Apart from transient hypocalcemia in two patients, no significant adverse effects of pamidronate were noted. CONCLUSION: This study has shown that the early rapid bone loss that occurs in men during the first 12 months after renal transplantation can be prevented by two intravenous doses of pamidronate given at transplantation and one month later. The regimen was simple to administer, well tolerated and potentially applicable to other clinical groups of glucocorticoid treatment patients.
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Authors | S L Fan, M K Almond, E Ball, K Evans, J Cunningham |
Journal | Kidney international
(Kidney Int)
Vol. 57
Issue 2
Pg. 684-90
(Feb 2000)
ISSN: 0085-2538 [Print] United States |
PMID | 10652047
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents
- Diphosphonates
- Parathyroid Hormone
- Phosphates
- Creatinine
- Aluminum
- Alkaline Phosphatase
- Pamidronate
- Calcium
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Topics |
- Absorptiometry, Photon
- Adult
- Aged
- Alkaline Phosphatase
(blood)
- Aluminum
(blood)
- Anti-Inflammatory Agents
(administration & dosage)
- Bone Diseases, Metabolic
(diagnostic imaging, drug therapy, prevention & control)
- Cadaver
- Calcium
(blood)
- Creatinine
(blood)
- Diphosphonates
(administration & dosage)
- Femur Neck
(pathology)
- Humans
- Immunosuppression Therapy
- Kidney Failure, Chronic
(surgery)
- Kidney Transplantation
- Lumbar Vertebrae
(pathology)
- Male
- Middle Aged
- Pamidronate
- Parathyroid Hormone
(blood)
- Phosphates
(blood)
- Postoperative Complications
(drug therapy, pathology, prevention & control)
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