Impact of nafarelin and leuprolide for endometriosis on quality of life and subjective clinical measures.

Abstract

OBJECTIVE:

To examine the impact of treating endometriosis with nafarelin or leuprolide acetate depot on patient quality of life (QOL) and subjective clinical measures.

STUDY DESIGN:

A randomized, multicenter study was conducted on 192 women with endometriosis. Patients received nafarelin or leuprolide for six months and were followed for up to six months after treatment. QOL was defined by seven items, including symptom severity, daily activities, pain medication use and need for bed rest.

RESULTS:

No significant differences were found at baseline between treatments for patients with mild, moderate or no endometriosis symptoms. Those with severe symptoms of endometriosis at baseline and taking nafarelin had a significantly greater improvement in QOL at the last posttreatment visit than those receiving leuprolide (P < .01). Nafarelin was associated with significantly fewer days with moderate or severe hot flashes than leuprolide during treatment (P < .05) and with significantly fewer moderate or severe hypoestrogenic symptoms overall at three months of treatment (P < .05). Additionally, poorer QOL was significantly associated with hypoestrogenic and endometriosis symptoms.

CONCLUSION:

Treatment of endometriosis with nafarelin was associated with fewer days of moderate or severe hot flashes as compared to leuprolide and with greater improvement in QOL after treatment in patients with severe symptoms at baseline.

• Authors: S Z Zhao, L A Kellerman, C A Francisco, J M Wong
• Journal: The Journal of reproductive medicine (J Reprod Med) Vol. 44 Issue 12 Pg. 1000-6 (Dec 1999) ISSN: 0024-7758 [Print] United States
• PMID: 10649809 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Analgesics
• Fertility Agents, Female
• Hormones
• Nafarelin
• Leuprolide

Topics

• Adult
• Analgesics (therapeutic use)
• Bed Rest
• Endometriosis (drug therapy, pathology)
• Female
• Fertility Agents, Female (adverse effects, therapeutic use)
• Hormones (adverse effects, therapeutic use)
• Hot Flashes (chemically induced)
• Humans
• Leuprolide (adverse effects, therapeutic use)
• Middle Aged
• Nafarelin (adverse effects, therapeutic use)
• Pain (etiology)
• Quality of Life
• Severity of Illness Index
• Treatment Outcome