Abstract | OBJECTIVE: METHODS: RESULTS:
Arthritis induced by PG/PS is biphasic, progressing through an initial acute phase and a remission phase, which is followed by a persistent chronic phase. Daily administration of FK506 initiated during the remission phase significantly attenuated the onset and development of chronic joint inflammation. We observed a significant reduction in joint inflammation and swelling, an apparent suppression of pannus development, and minimal erosive damage to the articular cartilage and subchondral bone. Fully established chronic joint inflammation was also ameliorated by daily administration of FK506. Joint swelling and inflammation was significantly reduced by 5 days post-treatment with FK506 and the erosive activity associated with the pannus appeared diminished. The elevated expression of IL-6 and NO characteristic of chronic joint inflammation in the serum and in joint tissue was significantly reduced by FK506 treatment. CONCLUSION: Therapeutic administration of FK506 has a profound antiinflammatory effect on the development of the chronic, erosive arthritis induced by PG/PS. This attenuation in joint inflammation was associated with suppression of IL-6 and NO production systemically and locally in the joints. Our data suggest that FK506 may be effective in the treatment of chronic joint inflammation associated with rheumatoid arthritis.
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Authors | J W Fuseler, M Hearth-Holmes, M B Grisham, D Kang, F S Laroux, R E Wolf |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 27
Issue 1
Pg. 190-9
(Jan 2000)
ISSN: 0315-162X [Print] Canada |
PMID | 10648038
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Bacterial Proteins
- Immunosuppressive Agents
- Interleukin-6
- Nitric Oxide
- Tacrolimus
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Topics |
- Animals
- Arthritis
(drug therapy, metabolism, microbiology)
- Bacterial Proteins
- Female
- Immunosuppressive Agents
(pharmacology, therapeutic use)
- Interleukin-6
(biosynthesis)
- Nitric Oxide
(biosynthesis)
- Rats
- Rats, Inbred Lew
- Streptococcus
- Tacrolimus
(pharmacology, therapeutic use)
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