Abstract | PURPOSE:
Basal cell adenocarcinoma is a recently recognized entity among malignant tumors of the salivary glands. This entity has not received enough attention among ophthalmologists and ophthalmic pathologists. We recommend that basal cell adenocarcinoma be included in the differential diagnosis of lacrimal gland tumors. DESIGN: Case report. METHODS: In 1988 a lacrimal gland tumor was incompletely removed from the left orbit of a 36-year-old woman and diagnosed as "solid basaloid adenoid cystic carcinoma". Soon after, an exenteration of the orbit was performed. In 1998, upon review of the initial histopathology, the diagnosis of solid adenoid cystic carcinoma was changed to basal cell adenocarcinoma. RESULTS AND MAIN OUTCOME MEASURE: The pathologic findings included nests of basaloid cells with minimal atypia and incomplete palisading around the periphery. The cells were of two types. The first type were large, pale cells with round or oval nuclei, scanty cytoplasm, and ill-defined borders. The other type were smaller cells with hyperchromatic nuclei situated mainly near the periphery of the nests. There was no necrosis or perineural invasion. Mitotic figures were present. Cysts within the nests showed Alcian blue negative contents. Immunohistochemistry showed a positive reaction to cytokeratin and a negative reaction with smooth muscle actin (SMA). CONCLUSIONS:
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Authors | M Khalil, B Arthurs |
Journal | Ophthalmology
(Ophthalmology)
Vol. 107
Issue 1
Pg. 164-8
(Jan 2000)
ISSN: 0161-6420 [Print] United States |
PMID | 10647736
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Mucin-1
- S100 Proteins
- Keratins
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Topics |
- Adenocarcinoma
(diagnosis, metabolism, surgery)
- Adult
- Biomarkers, Tumor
(metabolism)
- Diagnosis, Differential
- Eye Neoplasms
(diagnosis, metabolism, surgery)
- Female
- Humans
- Immunoenzyme Techniques
- Keratins
(metabolism)
- Lacrimal Apparatus Diseases
(diagnosis, metabolism, surgery)
- Mucin-1
(metabolism)
- S100 Proteins
(metabolism)
- Tomography, X-Ray Computed
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