Abstract |
Increased gastrocnemius/soleus muscle tone in children with cerebral palsy may cause an equinus of the ankle. Botulinum toxin type A (BTX), a neuromuscular blocking agent, reduces muscle tone in various neuromuscular disorders. The safety and short-term efficacy of BTX injections were evaluated in a prospective, 3-month, double-blind, randomized clinical trial involving 114 children with cerebral palsy and dynamic equinus foot deformity. Outcome was determined by observational gait analysis, ankle range-of-motion measurements, and quantification of muscle denervation by nerve conduction. Patients in the BTX group demonstrated improved gait function and partial denervation of the injected muscle. No serious adverse events were reported.
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Authors | L A Koman, J F Mooney 3rd, B P Smith, F Walker, J M Leon |
Journal | Journal of pediatric orthopedics
(J Pediatr Orthop)
2000 Jan-Feb
Vol. 20
Issue 1
Pg. 108-15
ISSN: 0271-6798 [Print] United States |
PMID | 10641699
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
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Topics |
- Adolescent
- Botulinum Toxins, Type A
(therapeutic use)
- Cerebral Palsy
(complications)
- Child
- Child, Preschool
- Double-Blind Method
- Equinus Deformity
(drug therapy, etiology, physiopathology)
- Gait
- Humans
- Leg
- Muscle Spasticity
(drug therapy, etiology, physiopathology)
- Neuromuscular Agents
(therapeutic use)
- Neuromuscular Blockade
- Prospective Studies
- Range of Motion, Articular
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