Pregnancy luteoma with granulosa cell proliferation: an unusual hyperplastic lesion arising in pregnancy and mimicking an ovarian neoplasia.

Abstract

A pregnancy luteoma (PL) was incidentally found at a term cesarean section in a 27-year-old black woman without any endocrine abnormality. The lesion involved only the left ovary; it had a nodular and focal pseudoalveolar growth pattern and was associated with areas of tubular sertoliform component, consistent with granulosa cell proliferation. Immunohistochemistry revealed a diffuse positivity to Inhibin A, CD99, cytokeratin and vimentin. The ultrastructure was typical of steroid-producing cells. PL is a tumor-like lesion arising in pregnant women and often misdiagnosed as a neoplastic lesion; awareness of this rare entity and its differential diagnoses may avoid unnecessary surgery in young patients.

• Authors: S Piana, F F Nogales, S Corrado, L Cardinale, D Gusolfino, F Rivasi
• Journal: Pathology, research and practice (Pathol Res Pract) Vol. 195 Issue 12 Pg. 859-63 ( 1999) ISSN: 0344-0338 [Print] Germany
• PMID: 10631723 (Publication Type: Case Reports, Journal Article)

Chemical References

• 12E7 Antigen
• Antigens, CD
• Biomarkers, Tumor
• CD99 protein, human
• Cell Adhesion Molecules
• Inhibins

Topics

• 12E7 Antigen
• Adult
• Antigens, CD (analysis)
• Biomarkers, Tumor (analysis)
• Cell Adhesion Molecules (analysis)
• Cell Division
• Diagnosis, Differential
• Female
• Granulosa Cells (chemistry, pathology)
• Humans
• Immunohistochemistry
• Inhibins (analysis)
• Luteoma (chemistry, diagnosis)
• Ovarian Neoplasms (chemistry, diagnosis)
• Pregnancy
• Pregnancy Complications, Neoplastic (diagnosis)