Beneficial effect of short-term endurance training on glucose metabolism during rehabilitation after coronary bypass surgery.

Abstract

AIMS:

Our study was aimed at determining whether beneficial modification of carbohydrate metabolism can be obtained after a short-term training program and whether it is associated with an increase in binding and degradation of (125)I-insulin by erythrocyte receptors that suggests a decrease in insulin resistance.

METHODS:

The study was conducted in a group of 20 patients aged 56 +/- 1.9 years (mean +/- SEM), within 1 to 6 months after coronary bypass surgery. All patients completed 15 training sessions based on 30 min of cycling with a constant load. Before and after a 3-week training program, glucose, insulin, and C-peptide blood levels, as well as binding and degradation of (125)I-insulin by erythrocyte receptors, were determined.

RESULTS:

A statistically significant decrease was found in the blood glucose level, from 111.2 +/- 4.2 to 97.8 +/- 3.5 mg/dL (p < 0.01); this decrease was not accompanied by significant insulin concentration changes. There was also a significant increase in insulin binding, from 0.535 +/- 0.059 to 0.668 +/- 0.042 pg (125)I/10(11) RBCs (p < 0.01), and degradation from 7.64 +/- 0.54 to 9.49 +/- 0.58 pg (125)I/10(11) RBCs (p < 0.05).

CONCLUSION:

The results indicated that even short-term endurance training in patients rehabilitated after coronary bypass surgery induced favorable modification of glucose metabolism, presumably caused by a decrease in insulin resistance.

• Authors: P Dylewicz, S Bienkowska, L Szczesniak, T Rychlewski, I Przywarska, M Wilk, A Jastrzebski
• Journal: Chest (Chest) Vol. 117 Issue 1 Pg. 47-51 (Jan 2000) ISSN: 0012-3692 [Print] United States
• PMID: 10631198 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Blood Glucose
• C-Peptide
• Insulin
• Lipids

Topics

• Adult
• Aged
• Blood Glucose (metabolism)
• Body Mass Index
• C-Peptide (blood)
• Coronary Artery Bypass
• Coronary Disease (blood, rehabilitation, surgery)
• Exercise (physiology)
• Exercise Therapy
• Humans
• Insulin (blood)
• Insulin Resistance (physiology)
• Lipids (blood)
• Male
• Middle Aged
• Treatment Outcome