Benzydamine hydrochloride oral rinses in management of burning mouth syndrome. A clinical trial.

Abstract

OBJECTIVE:

The purpose of this study was to evaluate the efficacy of the topical use of benzydamine hydrochloride 0.15% oral mouthwashes in the control of burning mouth syndrome symptoms.

STUDY DESIGN:

In this double-blind, randomized, longitudinal investigation, each of 30 patients with burning mouth syndrome was assigned to one of 3 management modalities. Those in group A received an oral rinse solution of benzydamine hydrochloride 0.15% 3 times a day for 4 weeks, those in group B received a placebo 3 times a day for 4 weeks, and those in group C did not receive any kind of treatment. A visual analog scale was used for evaluation of the symptoms; a Kruskal-Wallis analysis of variance exact test was performed on the resulting data.

RESULTS:

The findings of this investigation failed to reveal significant differences among the groups.

CONCLUSIONS:

The clinical application of benzydamine hydrochloride oral rinses in the treatment of patients with burning mouth syndrome did not demonstrate significative efficacy in comparison with use of a placebo solution.

• Authors: A Sardella, D Uglietti, F Demarosi, G Lodi, C Bez, A Carrassi
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 88 Issue 6 Pg. 683-6 (Dec 1999) ISSN: 1079-2104 [Print] United States
• PMID: 10625850 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents
• Anti-Inflammatory Agents, Non-Steroidal
• Mouthwashes
• Benzydamine

Topics

• Administration, Topical
• Aged
• Aged, 80 and over
• Anti-Inflammatory Agents (adverse effects, therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects, therapeutic use)
• Benzydamine (adverse effects, therapeutic use)
• Burning Mouth Syndrome (diagnosis, drug therapy)
• Chronic Disease
• Double-Blind Method
• Female
• Humans
• Longitudinal Studies
• Male
• Middle Aged
• Mouthwashes (adverse effects, therapeutic use)
• Treatment Failure