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A prospective, controlled, randomized study of the effect of a slow-release silver device on the frequency of urinary tract infection in newly catheterized patients.

AbstractOBJECTIVE:
To test the effect on urinary tract infections (UTIs) in patients needing continuous indwelling catheterization, of a newly designed urine-collecting system containing an antibacterial device which slowly releases silver ions onto the inner surface of the system.
PATIENTS AND METHODS:
The study comprised a prospective controlled randomized trial; 213 patients fulfilled the inclusion criteria. They were randomized to a urine drainage system (comprising a Unometer 400 metering system or PP 2000N closed urine-bag system, both from Maersk Medical, Denmark) either with or without the antibacterial device. The efficacy was assessed as the number of UTIs and the time to infection in the 170 patients eligible for analysis.
RESULTS:
There were fewer UTIs in those using the system containing the antibacterial device (19% vs 24%), but the difference was not statistically significant (P < 0.05).
CONCLUSION:
The potential importance of different infection routes were highlighted, suggesting that modifications to Foley catheters and urine-collecting systems attempting to prevent UTIs should focus not only on the intraluminal pathway, but on the internal and external pathways of infection.
AuthorsT Reiche, G Lisby, S Jørgensen, A B Christensen, J Nordling
JournalBJU international (BJU Int) Vol. 85 Issue 1 Pg. 54-9 (Jan 2000) ISSN: 1464-4096 [Print] England
PMID10619946 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Delayed-Action Preparations
  • Silver
Topics
  • Adult
  • Aged
  • Anti-Bacterial Agents (administration & dosage)
  • Catheters, Indwelling
  • Delayed-Action Preparations
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Silver (administration & dosage)
  • Treatment Outcome
  • Urinary Catheterization (adverse effects, instrumentation)
  • Urinary Tract Infections (prevention & control)

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