Abstract | STUDY OBJECTIVE: METHODS: This study used a secondary analysis of data collected in a prospective, randomized study, primarily designed to assess the effects of acid buffers in a canine model of cardiac arrest. VF was electrically induced. After 10 minutes, CPR was initiated, including ventilation with FIO(2)=1.0, external chest compressions, administration of epinephrine (0.1 mg/kg repeated every 5 minutes) and defibrillation. Animals were randomized to receive either NaHCO(3), Carbicarb, tromethamine (THAM), or NaCl. The hemodynamic variables were sampled from each experiment's paper chart at 1-minute intervals, and the responses to the first 4 doses of epinephrine were compared. RESULTS: Thirty-six animals (9 in each buffer group) were included in this analysis. Systolic, diastolic, and coronary perfusion pressures increased steeply (by 100%, 130%, and 190%, respectively) only after the first epinephrine dose. These pressures peaked at 2 to 3 minutes and decreased only slightly and insignificantly during the rest of the 5-minute interval, until the next epinephrine dose. No further significant increases in arterial pressures were observed in response to the next 3 doses of epinephrine, administered 5 minutes apart. CONCLUSION: The hemodynamic effects of high-dose epinephrine (0.1 mg/kg) during CPR appear to last longer than 5 minutes. Therefore, longer intervals between doses may be justified with high doses of epinephrine.
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Authors | G Bar-Joseph, T Weinberger, S Ben-Haim |
Journal | Annals of emergency medicine
(Ann Emerg Med)
Vol. 35
Issue 1
Pg. 3-10
(Jan 2000)
ISSN: 0196-0644 [Print] United States |
PMID | 10613934
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic alpha-Agonists
- Buffers
- Carbonates
- Drug Combinations
- Vasoconstrictor Agents
- sodium bicarbonate, sodium carbonate drug combination
- Tromethamine
- Sodium Chloride
- Sodium Bicarbonate
- Epinephrine
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Topics |
- Adrenergic alpha-Agonists
(administration & dosage, pharmacology)
- Animals
- Blood Pressure
(drug effects)
- Buffers
- Carbonates
(administration & dosage, pharmacology)
- Cardiopulmonary Resuscitation
(methods)
- Disease Models, Animal
- Dogs
- Drug Administration Schedule
- Drug Combinations
- Drug Evaluation, Preclinical
- Drug Therapy, Combination
- Epinephrine
(administration & dosage, pharmacology)
- Practice Guidelines as Topic
- Random Allocation
- Sodium Bicarbonate
(administration & dosage, pharmacology)
- Sodium Chloride
(administration & dosage, pharmacology)
- Time Factors
- Tromethamine
(administration & dosage, pharmacology)
- Vasoconstrictor Agents
(administration & dosage, pharmacology)
- Ventricular Fibrillation
(drug therapy, physiopathology)
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