[Biodistribution of 99mTC-HMPAO in healthy rats and B16 melanoma carriers].

Abstract

Scintigraphic studies carried out in melanoma patients have demonstrated that the 99mTc-HMPAO complex makes it possible to locate the lesion. A biodistribution and pharmacokinetic study of the 99mTc-HMPAO complex was carried out in B16-melanoma tumor healthy and carrier mice after an intravenous injection. Radioactivity was measured in the liver, kidneys, spleen, stomach, brain, blood and tumor. It was seen that at 15 minutes of the injections, 40% of the total activity distributed in the animal body was recorded in the tumor. An interesting effect observed is an increase in the tissue distribution curves in both experimental groups at 1-2 hours post-injection. According to the seriated imaging study results with 99mTc-HMPAO in B16 melanoma bearing mice, the best image is obtained 10-30 minutes after the injection.

• Authors: C F Calderón, A Collazo, W Cepero, J C Rodríguez, M Montalvo, M Robustillo, A Avila, R M Pérez
• Journal: Revista espanola de medicina nuclear (Rev Esp Med Nucl) Vol. 18 Issue 6 Pg. 425-30 (Dec 1999) ISSN: 0212-6982 [Print] Spain
• Vernacular Title: Biodistribución de 99mTc-HMPAO en ratones sanos y portadores de melanoma B16.
• PMID: 10611568 (Publication Type: Journal Article)

Chemical References

• Radiopharmaceuticals
• Technetium Tc 99m Exametazime

Topics

• Animals
• Male
• Melanoma, Experimental (diagnostic imaging, metabolism)
• Mice
• Mice, Inbred Strains
• Radionuclide Imaging
• Radiopharmaceuticals (pharmacokinetics)
• Technetium Tc 99m Exametazime (pharmacokinetics)
• Tissue Distribution