Measurement of serum
fructosamine, 1-amino-1-deoxyfructose, is commonly used in diagnosing and monitoring hyperglycaemic disorders, such as
diabetes mellitus in dogs. Serum
fructosamine indicates long-term serum
glucose concentrations and replaces serial serum
glucose measurements. This study investigates the clinical usefulness of serum
fructosamine in differentiating conditions other than
diabetes mellitus characterised by glucosuria. Four dogs presented with glucosuria all had serum
fructosamine concentrations within or close to the reference range (313 micromol 1(-1), 291 micromol 1(-1), 348 micromol 1(-1), 262 micromol 1(-1) reference range: 250 to 320 micromol 1(-1) indicating that a single serum
fructosamine measurement is a simple and efficient way of verifying concurrent persistent normoglycaemia. Therefore, serum
fructosamine is a useful parameter not only in diabetic patients, bu also in differentiating conditions in dogs characterised by glucosuria without hyperglycaemia, such as primary
renal glucosuria and the
Fanconi syndrome. To distinguish between primary
renal glucosuria and the
Fanconi syndrome, measurement of the
amino acid concentration in urine was performed.