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Molecular basis of defence against oxidative stress in Entamoeba histolytica and Giardia lamblia.

Abstract
Gastrointestinal protozoa, viz. Entamoeba histolytica and Giardia, are able to survive in a microaerobic environment. The role of parasitic factors, particularly cysteine, cysteine-rich proteins, superoxide dismutase, and certain alternative mechanisms, has been described in the defence against oxidative stress. The role of the host-derived factors, particularly the phagocytosis of bacteria or host erythrocytes (intact or their enzymatic/non enzymatic components), in the detoxification of reactive oxygen metabolites in E. histolytica may provide novel approaches for the chemotherapy of invasive amoebiasis.
AuthorsB L Tekwani, R K Mehlotra
JournalMicrobes and infection (Microbes Infect) Vol. 1 Issue 5 Pg. 385-94 (Apr 1999) ISSN: 1286-4579 [Print] France
PMID10602671 (Publication Type: Journal Article, Review)
Topics
  • Animals
  • Entamoeba histolytica (enzymology, growth & development, metabolism, pathogenicity)
  • Giardia lamblia (enzymology, growth & development, metabolism, pathogenicity)
  • Host-Parasite Interactions
  • Humans
  • Oxidative Stress

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