Abstract |
Gastrointestinal protozoa, viz. Entamoeba histolytica and Giardia, are able to survive in a microaerobic environment. The role of parasitic factors, particularly cysteine, cysteine-rich proteins, superoxide dismutase, and certain alternative mechanisms, has been described in the defence against oxidative stress. The role of the host-derived factors, particularly the phagocytosis of bacteria or host erythrocytes (intact or their enzymatic/non enzymatic components), in the detoxification of reactive oxygen metabolites in E. histolytica may provide novel approaches for the chemotherapy of invasive amoebiasis.
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Authors | B L Tekwani, R K Mehlotra |
Journal | Microbes and infection
(Microbes Infect)
Vol. 1
Issue 5
Pg. 385-94
(Apr 1999)
ISSN: 1286-4579 [Print] France |
PMID | 10602671
(Publication Type: Journal Article, Review)
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Topics |
- Animals
- Entamoeba histolytica
(enzymology, growth & development, metabolism, pathogenicity)
- Giardia lamblia
(enzymology, growth & development, metabolism, pathogenicity)
- Host-Parasite Interactions
- Humans
- Oxidative Stress
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