Abstract | OBJECTIVES: METHODS: RESULTS: Staining intensity was strong in 44 (36%) samples, while 24 (19%) specimens remained syndecan-1-negative. In 49 (40%) samples, the percentage of syndecan-1-positive cells was >/=90%. Syndecan-1 expression, as determined by >/=50% positively stained tumor cells, was associated with the grade of differentiation (P = 0.03) and squamous histology (P < 0.001), but was not associated with clinical stage (P = 0.16) or disease-free survival (P = 0.86). Age (P = 0.003) and clinical stage (P < 0.001) were significant prognostic factors, but syndecan-1 expression determined neither by percentage of positively stained tumor cells nor by staining intensity was associated with the outcome. CONCLUSIONS: In cervical carcinoma syndecan-1 is associated with histological differentiation grade and squamous histology, but does not predict clinical outcome.
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Authors | M Rintala, P Inki, P Klemi, M Jalkanen, S Grénman |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 75
Issue 3
Pg. 372-8
(Dec 1999)
ISSN: 0090-8258 [Print] United States |
PMID | 10600292
(Publication Type: Journal Article)
|
Copyright | Copyright 1999 Academic Press. |
Chemical References |
- Membrane Glycoproteins
- Proteoglycans
- SDC1 protein, human
- Syndecan-1
- Syndecans
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
(chemistry, pathology)
- Female
- Humans
- Immunohistochemistry
- Membrane Glycoproteins
(analysis)
- Middle Aged
- Neoplasm Staging
- Prognosis
- Proteoglycans
(analysis)
- Syndecan-1
- Syndecans
- Uterine Cervical Neoplasms
(chemistry, mortality, pathology)
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