[Solitary fibrous tumor of the pleura with elevated high-molecular-weight insulin-like growth factor II and hypoglycemia].

Abstract

Recurrent hypoglycemia occurred in a 58-year-old woman with a solitary fibrous tumor of the pleura and exhibiting CD34 immunopositivity. During episodes of hypoglycemia, serum high-molecular-weight insulin-like growth factor II (big IGF-II) was elevated. After removal of the tumor containing IGF-II, the hypoglycemia and serum big IGF-II disappeared. This was followed by an increase in normal IGF-II. We speculate that the primary cause of hypoglycemia in this patient was the presence of big IGF-II produced by the solitary fibrous tumor of the pleura. To our knowledge, the presence of this type of IGF-II in CD34+ solitary fibrous tumors of the pleura has not been described to date in the literature.

• Authors: K Mori, Y Ohtsuki, N Hizuka
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 37 Issue 10 Pg. 834-40 (Oct 1999) ISSN: 1343-3490 [Print] Japan
• PMID: 10586596 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Insulin-Like Growth Factor II

Topics

• Female
• Humans
• Hypoglycemia (etiology)
• Insulin-Like Growth Factor II (biosynthesis, chemistry)
• Mesothelioma (complications, metabolism)
• Middle Aged
• Molecular Weight
• Pleural Neoplasms (complications, metabolism)