Abstract | BACKGROUND: Based on the observation of 7 patients with chronic IgA nephritis and on a course to end-stage renal failure after several years, D'Amico et al. [1993] reported on a "point of no return" at 2.5 to 3 mg/dl serum creatinine. After exceeding this limit all 7 patients exhibited an irreversible progressive renal failure. PATIENTS AND METHODS: RESULTS: Three different courses could be distinguished: a stable chronic course with constantly normal or only minor elevated serum creatinine lasting for years (91 patients), a progressive course with continuously increasing serum creatinine (22 patients), and a rare (only 2 patients) early acute course with a short-term increase of serum creatinine followed by a rapid return to the normal range. After exceeding 3 mg/dl serum creatinine no remissions were observed in the progressive cases. Sixteen patients showed a rapid, continuously progressive course until end-stage renal failure with exactly the same progression as the 7 patients of D'Amico et al. Six patients of the 22 progressors were not observed long enough. The serum creatinine level doubled on average from 3 to 6 mg/dl within 10 months. CONCLUSION: Our study confirmed the existence of a "point of no return" at 3 mg/dl (265 micromol/l) during the natural course of chronic IgA nephritis.
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Authors | U Schöll, U Wastl, T Risler, N Braun, B Grabensee, P Heering, P Schollmeyer, I Zäuner, G Stein, R Fünfstück, F Keller |
Journal | Clinical nephrology
(Clin Nephrol)
Vol. 52
Issue 5
Pg. 285-92
(Nov 1999)
ISSN: 0301-0430 [Print] Germany |
PMID | 10584991
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Chronic Disease
- Creatinine
(blood)
- Disease Progression
- Female
- Glomerulonephritis, IGA
(blood, complications)
- Humans
- Kidney Failure, Chronic
(etiology)
- Male
- Middle Aged
- Prognosis
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