Hepatitis A virus-specific humoral and cellular immune responses following immunization with a formalin-inactivated hepatitis A vaccine.

Abstract

To evaluate proliferative T cell responses elicited by a formalin-inactivated HAV vaccine, we immunized 10 subjects with an inactivated HAV vaccine, and measured HAV antibody titers and HAV-specific T cell proliferation. gamma-Interferon production by PBMC's was evaluated in selected subjects. By week 30, seroconversion (geometric mean titer=2299 mIU/ml), and HAV-specific proliferation was detected in all subjects. HAV also induced gamma-interferon in the three subjects studied. These data indicate that the inactivated HAV vaccine induces proliferative T cell responses in addition to HAV antibody. This may be important for protection against hepatitis A, and suggests that recall memory for HAV antigen is elicited by the vaccine.

• Authors: J B Cederna, D Klinzman, J T Stapleton
• Journal: Vaccine (Vaccine) Vol. 18 Issue 9-10 Pg. 892-8 (Dec 10 1999) ISSN: 0264-410X [Print] Netherlands
• PMID: 10580203 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hepatitis A Vaccines
• Hepatitis Antibodies
• Vaccines, Inactivated
• Viral Hepatitis Vaccines
• Formaldehyde

Topics

• Adult
• Female
• Formaldehyde
• Hepatitis A Vaccines
• Hepatitis A Virus, Human (immunology)
• Hepatitis Antibodies (biosynthesis)
• Humans
• Male
• T-Lymphocytes (drug effects, immunology)
• Vaccines, Inactivated (immunology)
• Viral Hepatitis Vaccines (immunology)