Effect of dietary xylitol on growth and inflammatory responses in immune stimulated chickens.

Abstract

It has been argued that stimulation of the immune system depresses performance. Accordingly, an experiment was conducted to determine the effect of dietary xylitol (150 g/kg diet) on growth and selected inflammatory responses in male broiler chickens. During the final 6 d of the experimental periods, chicks were injected with antigens: Escherichia coli lipopolysaccharide (LPS) on days 1, 3 and 5 and with Sephadex-G50 superfine on days 2 and 4 to stimulate macrophage functions. The immune stimulation reduced body weight gain and food intake, but enhanced alpha 1 acid glycoprotein (AGP) concentration and interleukin (IL-1) like activity in plasma. Feeding the xylitol diet partially, but significantly, prevented the reductions in body weight gain and food intake, without affecting the early stage of inflammatory responses triggered by LPS and Sephadex injections.

• Authors: K Takahashi, K Onodera, Y Akiba
• Journal: British poultry science (Br Poult Sci) Vol. 40 Issue 4 Pg. 552-4 (Sep 1999) ISSN: 0007-1668 [Print] England
• PMID: 10579417 (Publication Type: Journal Article)

Chemical References

• Dextrans
• Interleukin-1
• Lipopolysaccharides
• Orosomucoid
• sephadex
• Zinc
• Xylitol

Topics

• Animal Feed
• Animals
• Chickens (growth & development, physiology)
• Dextrans (toxicity)
• Diet
• Energy Intake (drug effects)
• Escherichia coli
• Inflammation (physiopathology)
• Interleukin-1 (blood)
• Lipopolysaccharides (toxicity)
• Macrophages (drug effects, immunology)
• Male
• Orosomucoid (metabolism)
• Weight Gain (drug effects)
• Xylitol (administration & dosage, pharmacology)
• Zinc (blood)