Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals.

Abstract	The secreted proteins Wingless and Hedgehog are essential to the elaboration of the denticle pattern in the epidermis of Drosophila embryos. We show that signaling by Wingless and Hedgehog regulates the expression of veinlet (rhomboid) and Serrate, two genes expressed in prospective denticle belts. Thus, Serrate and veinlet (rhom) partake in the last layer of the segmentation cascade. Ultimately, Wingless, Hedgehog, Veinlet (an indirect activator of the Egfr) and Serrate (an activator of Notch) are expressed in non-overlapping narrow stripes. The interface between any two stripes allows a reliable prediction of individual denticle types and polarity suggesting that contact-dependent signaling modulates individual cell fates. Attributes of a morphogen can be ascribed to Hedgehog in this system. However, no single morphogen organises the whole denticle pattern.
Authors	C Alexandre, M Lecourtois, J Vincent
Journal	Development (Cambridge, England) (Development) Vol. 126 Issue 24 Pg. 5689-98 (Dec 1999) ISSN: 0950-1991 [Print] England
PMID	10572045 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Calcium-Binding Proteins Drosophila Proteins Hedgehog Proteins Insect Proteins Intercellular Signaling Peptides and Proteins Jagged-1 Protein Membrane Proteins Proto-Oncogene Proteins Rho protein, Drosophila Ser protein, Drosophila Serrate-Jagged Proteins Stet protein, Drosophila Wnt1 Protein wg protein, Drosophila hh protein, Drosophila
Topics	Animals Body Patterning Calcium-Binding Proteins Drosophila Proteins Drosophila melanogaster (embryology) Gene Expression Regulation, Developmental Hedgehog Proteins Insect Proteins (genetics) Intercellular Signaling Peptides and Proteins Jagged-1 Protein Membrane Proteins (genetics) Proto-Oncogene Proteins (genetics) Serrate-Jagged Proteins Signal Transduction Wnt1 Protein

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