Abstract | BACKGROUND: METHODS: To determine if this effect can increase the risk of acute urate nephropathy, 63 hypertensive patients with thiazide-induced asymptomatic hyperuricemia (serum uric acid 7.0 to 12.0 mg/dl) were randomized double-blind to losartan 50 mg every day (q.d.), losartan 50 mg plus hydrochlorothiazide ( HCTZ) 50 mg q.d., HCTZ 50 mg q.d., or placebo for three weeks. To potentiate the risk of crystal formation, patients received a 2 g/kg protein diet one day prior to each clinic visit on days 0 (baseline), 1, 7, and 21. RESULTS: Adverse events typically associated with acute urate nephropathy, for example, flank pain, hematuria, or increased blood urea nitrogen/ creatinine, were not reported. Uric acid excretion and urine pH increased four and six hours after losartan on day 1 compared with day 0. Dihydrogen urate, the primary risk factor for crystal formation, decreased at four and six hours on day 1 compared with day 0 associated with the concurrent rise in urine pH. Day 7 and 21 changes, compared with day 0, in uric acid excretion rate, urine pH, and dihydrogen urate with losartan were comparable to day 1 results but were not statistically significant. Serum uric acid was significantly reduced after 21 days of therapy with losartan. CONCLUSION:
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Authors | S Shahinfar, R L Simpson, A D Carides, B Thiyagarajan, Y Nakagawa, J G Umans, J H Parks, F L Coe |
Journal | Kidney international
(Kidney Int)
Vol. 56
Issue 5
Pg. 1879-85
(Nov 1999)
ISSN: 0085-2538 [Print] United States |
PMID | 10571797
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Benzothiadiazines
- Diuretics
- Sodium Chloride Symporter Inhibitors
- Uric Acid
- Losartan
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Topics |
- Adult
- Aged
- Antihypertensive Agents
(adverse effects)
- Benzothiadiazines
- Diuretics
- Double-Blind Method
- Female
- Humans
- Hydrogen-Ion Concentration
- Hypertension
(blood, drug therapy)
- Losartan
(adverse effects)
- Male
- Middle Aged
- Sodium Chloride Symporter Inhibitors
(adverse effects)
- Uric Acid
(blood)
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