Tamoxifen versus placebo in the treatment of Peyronie's disease.

Abstract

PURPOSE:

We evaluated the effects of oral tamoxifen and placebo in patients with Peyronie's disease.

MATERIALS AND METHODS:

We selected 25 patients with Peyronie's disease who did not have calcified plaque for treatment in the andrology outpatient clinic. A medical history was obtained, and physical examination, penile x-ray, penile ultrasound and pharmacologically induced erection with prostaglandin E1 were performed. Patients were randomly divided into group 1--those who received 20 mg. tamoxifen twice daily for 3 months and group 2--those who received placebo for the same period. The same evaluations were done 4 months later and results were compared. Qualitative (chi-square test) and quantitative (Student's t test) results were analyzed using the Yates correction factor with p <0.05 considered significant.

RESULTS:

Pain subsided in 66.6 and 75% of the patients treated with tamoxifen and placebo, respectively (p >0.05). In groups 1 and 2 a reduction in the penile deformity was noticed by 46.1 and 41.7% of the patients (p >0.05), and a decrease in plaque size was noticed by 30.7 and 25%, respectively. On the other hand, objective measurements did not reveal any difference in plaque area or curvature angle.

CONCLUSIONS:

This study did not show significant improvement in pain, curvature or plaque size in patients with Peyronie's disease who were treated with tamoxifen compared with those treated with placebo.

• Authors: C Teloken, E L Rhoden, T M Grazziotin, C T Ros, P R Sogari, C A Souto
• Journal: The Journal of urology (J Urol) Vol. 162 Issue 6 Pg. 2003-5 (Dec 1999) ISSN: 0022-5347 [Print] United States
• PMID: 10569556 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Tamoxifen

Topics

• Administration, Oral
• Aged
• Humans
• Male
• Middle Aged
• Penile Induration (drug therapy)
• Tamoxifen (administration & dosage)