Immunosuppressive effect of deoxyspergualin in proliferative glomerulonephritis.

Abstract

A clinical trial of the immunosuppressive drug deoxyspergualin (DSG) was conducted in five patients with various forms of proliferative glomerulonephritis (immunoglobulin A nephropathy in two patients, purpura nephritis in one patient, membranoproliferative glomerulonephritis in one patient, and rapidly progressive glomerulonephritis in one patient). DSG was intravenously administered at 0.25 or 0.5 mg/kg/d for 4 weeks. A marked decrease in proteinuria (to <50% of baseline) was observed in four patients, and the other patient showed a 38% reduction in proteinuria, but the proteinuria was exacerbated again after discontinuation of DSG in three patients during a 4-week follow-up period. Proinflammatory CD16(+) (FcgammaRIII) monocytes disappeared from the peripheral blood during the administration of DSG but reappeared after DSG treatment was discontinued. A significant decrease in urinary macrophage counts that was far more marked than the decrease in peripheral blood monocyte counts was observed after administration of DSG. Interestingly, we also observed that the CD16 marker on the CD14(+) macrophage population in the urine disappeared in response to DSG treatment. These findings suggest that DSG may have a unique effect of suppression of FcgammaRIII expression on monocytes and/or macrophages that may result in amelioration of activated macrophage-mediated glomerulonephritis.

• Authors: O Hotta, T Furuta, S Chiba, N Yusa, Y Taguma
• Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation (Am J Kidney Dis) Vol. 34 Issue 5 Pg. 894-901 (Nov 1999) ISSN: 0272-6386 [Print] United States
• PMID: 10561147 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Guanidines
• Immunosuppressive Agents
• Receptors, IgG
• gusperimus

Topics

• Adult
• Female
• Glomerulonephritis, IGA (drug therapy, immunology)
• Glomerulonephritis, Membranoproliferative (drug therapy, immunology)
• Guanidines (administration & dosage, adverse effects)
• Humans
• Immunosuppressive Agents (administration & dosage, adverse effects)
• Infusions, Intravenous
• Kidney Function Tests
• Macrophage Activation (drug effects, immunology)
• Macrophages (drug effects, immunology)
• Male
• Middle Aged
• Monocytes (drug effects, immunology)
• Receptors, IgG (metabolism)