Abstract |
Ewes were lutectomized and treatments were started 72 h later. Pregnant ewes were treated with vehicle; prostaglandin F2alpha ( PGF2alpha); cortisol (C); trilostane (TR), a 3beta-hydroxy-steroid dehydrogenase inhibitor; PGF2alpha + C; TR + PGF2alpha; TR + C, or TR + PGF2 + C. TR, TR + PGF2alpha, TR + C, and TR + PGF2alpha + C aborted (P < or = 0.05) all ewes receiving TR. One ewe treated with PGF2alpha aborted (P > or = 0.05). The average time to abortion of TR-treated ewes was 50.8 h (P < or = 0.05) after initiation of treatments. All aborted ewes had retained placentas (P < or = 0.05) except one ewe in the TR + PGF2alpha, treatment group. TR was given every 12 h starting at 72 h postlutectomy until 96 h postlutectomy. TR reduced (P < or = 0.05) progesterone. Estradiol-17beta was increased (P < or = 0.05) 2 h after the first two TR treatments and declined 2 h later and was followed by a sustained increase (P < or = 0.05) in estradiol-17beta, which was coincident with the onset of abortions. Estradiol-17beta was increased (P < or = 0.05) by PGF2alpha but did not decrease (P > or = 0.05) placental secretion of progesterone. It is concluded that TR but not PGF2alpha is an abortifacient in 90-day-pregnant lutectomized ewes and that abortion occurs only when there is a decrease in circulating progesterone and an increase in circulating estradiol-17beta.
|
Authors | Y S Weems, D L Vincent, C Lemme, C W Weems |
Journal | Prostaglandins & other lipid mediators
(Prostaglandins Other Lipid Mediat)
Vol. 58
Issue 2-4
Pg. 77-86
(Oct 1999)
ISSN: 1098-8823 [Print] United States |
PMID | 10560611
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
- Abortifacient Agents, Steroidal
- Enzyme Inhibitors
- Dihydrotestosterone
- Progesterone
- Estradiol
- Dinoprost
- 3-Hydroxysteroid Dehydrogenases
- trilostane
- Hydrocortisone
|
Topics |
- 3-Hydroxysteroid Dehydrogenases
(antagonists & inhibitors)
- Abortifacient Agents, Steroidal
(pharmacology)
- Abortion, Induced
(veterinary)
- Abortion, Veterinary
- Animals
- Corpus Luteum
(physiology, surgery)
- Dihydrotestosterone
(analogs & derivatives, pharmacology)
- Dinoprost
(pharmacology)
- Enzyme Inhibitors
(pharmacology)
- Estradiol
(blood)
- Female
- Hydrocortisone
(pharmacology)
- Organ Size
- Placenta
(physiology)
- Pregnancy
- Pregnancy, Animal
(drug effects)
- Progesterone
(metabolism)
- Sheep
- Time Factors
|