A case of Werner's syndrome associated with osteosarcoma.

Abstract

We described a case of Werner's syndrome associated with osteosarcoma. A 37-year-old Japanese man was diagnosed as having Werner's syndrome by the presence of juvenile cataracts, skin sclerosis and hyperpigmentation of the feet, high-pitched voice, characteristic bird-like appearance of the face with beak-shaped nose, thinning of the entire skin and hyperkeratoses on soles, hyperlipemia, hyperuricemia, diabetes melitus, and the mutated responsible gene (WRN). He had a 3-month history of a tumor on his left forearm. Histologically, the tumor included four histological patterns; a malignant fibrous histiocytoma-like, a desmoid-like, a dermatofibrosarcoma protuberans-like, and a chondrosarcoma-like pattern. Tumoral osteoid formation was also found in the tumor. Therefore, the tumor was diagnosed as osteosarcoma.

• Authors: K Murata, A Hatamochi, H Shinkai, Y Ishikawa, N Kawaguchi, M Goto
• Journal: The Journal of dermatology (J Dermatol) Vol. 26 Issue 10 Pg. 682-6 (Oct 1999) ISSN: 0385-2407 [Print] England
• PMID: 10554436 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Adult
• Amputation, Surgical
• Bone Neoplasms (diagnosis, etiology, surgery)
• Follow-Up Studies
• Humans
• Male
• Osteosarcoma (diagnosis, etiology, surgery)
• Pedigree
• Radius
• Treatment Outcome
• Werner Syndrome (complications, diagnosis, genetics, therapy)