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Bioconjugation of laminin-related peptide YIGSR with polyvinyl pyrrolidone increases its antimetastatic effect due to a longer plasma half-life.

Abstract
Polyvinyl pyrrolidone (PVP) which can be radically synthesized and have a long blood residency was used to modify the laminin-related peptide YIGSR, and its inhibitory effect on experimental lung metastasis of B16-BL6 melanoma cells was examined. The antimetastatic effect of PVP-conjugated YIGSR (PVP-YIGSR) was more than 100-fold greater than that of native YIGSR. When injected intravenously, PVP-YIGSR showed more than a 15-fold longer plasma half-life relative to native YIGSR. In addition, the stability of YIGSR in plasma was increased by conjugation with PVP. These findings suggest that PVP is a useful polymeric modifier for increasing the antimetastatic activity of YIGSR.
AuthorsY Mu, H Kamada, H Kodaira, K Sato, Y Tsutsumi, M Maeda, K Kawasaki, M Nomizu, Y Yamada, T Mayumi
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 264 Issue 3 Pg. 763-7 (Nov 02 1999) ISSN: 0006-291X [Print] United States
PMID10544005 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 1999 Academic Press.
Chemical References
  • Antineoplastic Agents
  • Drug Carriers
  • Laminin
  • Oligopeptides
  • Pharmaceutic Aids
  • tyrosyl-isoleucyl-glycyl-seryl-arginine
  • Povidone
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, chemistry, pharmacokinetics)
  • Drug Carriers
  • Drug Delivery Systems
  • Half-Life
  • Laminin
  • Lung Neoplasms (drug therapy, secondary)
  • Mice
  • Neoplasm Transplantation
  • Oligopeptides (administration & dosage, chemistry, pharmacokinetics)
  • Pharmaceutic Aids (administration & dosage, chemistry, pharmacokinetics)
  • Povidone (administration & dosage, chemistry, pharmacokinetics)
  • Tumor Cells, Cultured

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