Abstract |
Polyvinyl pyrrolidone (PVP) which can be radically synthesized and have a long blood residency was used to modify the laminin-related peptide YIGSR, and its inhibitory effect on experimental lung metastasis of B16-BL6 melanoma cells was examined. The antimetastatic effect of PVP-conjugated YIGSR (PVP- YIGSR) was more than 100-fold greater than that of native YIGSR. When injected intravenously, PVP- YIGSR showed more than a 15-fold longer plasma half-life relative to native YIGSR. In addition, the stability of YIGSR in plasma was increased by conjugation with PVP. These findings suggest that PVP is a useful polymeric modifier for increasing the antimetastatic activity of YIGSR.
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Authors | Y Mu, H Kamada, H Kodaira, K Sato, Y Tsutsumi, M Maeda, K Kawasaki, M Nomizu, Y Yamada, T Mayumi |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 264
Issue 3
Pg. 763-7
(Nov 02 1999)
ISSN: 0006-291X [Print] United States |
PMID | 10544005
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 1999 Academic Press. |
Chemical References |
- Antineoplastic Agents
- Drug Carriers
- Laminin
- Oligopeptides
- Pharmaceutic Aids
- tyrosyl-isoleucyl-glycyl-seryl-arginine
- Povidone
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, chemistry, pharmacokinetics)
- Drug Carriers
- Drug Delivery Systems
- Half-Life
- Laminin
- Lung Neoplasms
(drug therapy, secondary)
- Mice
- Neoplasm Transplantation
- Oligopeptides
(administration & dosage, chemistry, pharmacokinetics)
- Pharmaceutic Aids
(administration & dosage, chemistry, pharmacokinetics)
- Povidone
(administration & dosage, chemistry, pharmacokinetics)
- Tumor Cells, Cultured
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