In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp.

Abstract

The in vitro antimicrobial susceptibilities of isolates of Burkholderia mallei to 16 antibiotics were assessed and compared with the susceptibilities of Burkholderia pseudomallei and Burkholderia cepacia. The antibiotic susceptibility profile of B. mallei resembled that of B. pseudomallei more closely than that of B. cepacia, which corresponds to their similarities in terms of biochemistry, antigenicity, and pathogenicity. Ceftazidime, imipenem, doxycycline, and ciprofloxacin were active against both B. mallei and B. pseudomallei. Gentamicin was active against B. mallei but not against B. pseudomallei. Antibiotics clinically proven to be effective in the treatment of melioidosis may therefore be effective for treating glanders.

• Authors: D J Kenny, P Russell, D Rogers, S M Eley, R W Titball
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 43 Issue 11 Pg. 2773-5 (Nov 1999) ISSN: 0066-4804 [Print] United States
• PMID: 10543761 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents

Topics

• Anti-Bacterial Agents (pharmacology)
• Burkholderia (drug effects)
• Burkholderia Infections (microbiology)
• Burkholderia pseudomallei (drug effects)
• Humans
• Microbial Sensitivity Tests
• Quality Control