Thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation: incidence and significance in patients with breast cancer.

Abstract

OBJECTIVE:

The purpose of this study was to determine the incidence and clinical significance of thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation for treatment of metastatic or high-risk primary (with at least four positive lymph nodes) breast cancer.

MATERIALS AND METHODS:

We retrospectively reviewed clinical records and CT scans of 102 breast cancer patients treated with high-dose chemotherapy and autologous stem cell transplantation. Patients were 26-63 years old (mean, 46 years). The length and width of the thymus gland were measured on serial CT scans obtained before and after treatment. Moderate thymic hyperplasia was recorded if a focal or diffuse increase was seen in the oblong, triangular soft-tissue opacity conforming to the configuration of the normal gland within the anterior mediastinum after therapy. Minimal hyperplasia was recorded when a minimal increase was seen in soft-tissue attenuation conforming to the configuration of the normal bilobed thymus gland within the anterior mediastinum, but no discrete mass was visible.

RESULTS:

CT showed no thymic hyperplasia in 91 (89%) of the 102 patients. CT showed thymic hyperplasia in the other 11 patients (11%). Three patients (3%) had moderate hyperplasia, and eight patients (8%) had minimal hyperplasia. When comparing patients with and without hyperplasia, we found no difference in mean age or survival.

CONCLUSION:

Thymic hyperplasia is rare after high-dose chemotherapy and autologous stem cell transplantation in adult patients with metastatic or high-risk primary breast cancer. In this population, thymic hyperplasia does not appear to correlate with survival.

• Authors: M Hara, H P McAdams, J J Vredenburgh, J E Herndon, E F Patz Jr
• Journal: AJR. American journal of roentgenology (AJR Am J Roentgenol) Vol. 173 Issue 5 Pg. 1341-4 (Nov 1999) ISSN: 0361-803X [Print] United States
• PMID: 10541115 (Publication Type: Journal Article)

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Breast Neoplasms (drug therapy, pathology)
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Hematopoietic Stem Cell Transplantation
• Humans
• Lymphatic Metastasis
• Middle Aged
• Neoplasm Staging
• Thymus Gland (pathology)
• Thymus Hyperplasia (chemically induced, pathology)
• Tomography, X-Ray Computed