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Successful treatment of cerebral aspergillosis with a high oral dose of itraconazole after excisional surgery.

Abstract
We report a case of cerebral aspergillosis which originated from the sphenoid sinus, and involved a progressive decrease of visual acuity. The neurological signs indicated a cavernous sinus invasion. After extensive intracranial surgery we treated the residual aspergillosis with a high oral dose of itraconazole (800 mg/d for 4 months, followed by 400 mg/d for 5 months). The neurological impairments of the patient gradually subsided with the resolution of the fungal lesion shown on MRI. The successful therapy indicated that itraconazole has a significant role in the treatment of advanced cerebral aspergillosis if it is used in high doses (16 mg/kg/d for adults).
AuthorsT Imai, T Yamamoto, S Tanaka, M Kashiwagi, S Chiba, H Matsumoto, T Uede
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 38 Issue 10 Pg. 829-32 (Oct 1999) ISSN: 0918-2918 [Print] Japan
PMID10526950 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antifungal Agents
  • Itraconazole
Topics
  • Administration, Oral
  • Antifungal Agents (administration & dosage)
  • Aspergillosis (drug therapy, surgery)
  • Brain Abscess (drug therapy, microbiology, surgery)
  • Cerebral Cortex (microbiology)
  • Combined Modality Therapy
  • Diabetes Complications
  • Humans
  • Itraconazole (administration & dosage)
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged

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