Abstract |
We report a case of cerebral aspergillosis which originated from the sphenoid sinus, and involved a progressive decrease of visual acuity. The neurological signs indicated a cavernous sinus invasion. After extensive intracranial surgery we treated the residual aspergillosis with a high oral dose of itraconazole (800 mg/d for 4 months, followed by 400 mg/d for 5 months). The neurological impairments of the patient gradually subsided with the resolution of the fungal lesion shown on MRI. The successful therapy indicated that itraconazole has a significant role in the treatment of advanced cerebral aspergillosis if it is used in high doses (16 mg/kg/d for adults).
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Authors | T Imai, T Yamamoto, S Tanaka, M Kashiwagi, S Chiba, H Matsumoto, T Uede |
Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 38
Issue 10
Pg. 829-32
(Oct 1999)
ISSN: 0918-2918 [Print] Japan |
PMID | 10526950
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antifungal Agents
- Itraconazole
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Topics |
- Administration, Oral
- Antifungal Agents
(administration & dosage)
- Aspergillosis
(drug therapy, surgery)
- Brain Abscess
(drug therapy, microbiology, surgery)
- Cerebral Cortex
(microbiology)
- Combined Modality Therapy
- Diabetes Complications
- Humans
- Itraconazole
(administration & dosage)
- Magnetic Resonance Imaging
- Male
- Middle Aged
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