Abstract | BACKGROUND: OBJECTIVE: To report the neuromuscular autoantibody profiles of three patients with a syndrome of MG and neuromuscular hyperexcitability. RESULTS: CONCLUSIONS: The coexistence of cramp-fasciculation syndrome and acquired rippling muscle syndrome with MG, thymoma, and neuronal AChR autoantibodies suggests that there is a continuum of autoimmune neuromuscular hyperexcitability disorders related pathogenically to Isaacs syndrome. Manifestations of neuromuscular hyperexcitability may be altered and less apparent in the context of MG because of the coexisting defect of neuromuscular transmission.
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Authors | S Vernino, R G Auger, A M Emslie-Smith, C M Harper, V A Lennon |
Journal | Neurology
(Neurology)
Vol. 53
Issue 6
Pg. 1233-9
(Oct 12 1999)
ISSN: 0028-3878 [Print] United States |
PMID | 10522878
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adult
- Autoantibodies
(immunology)
- Electromyography
- Female
- Humans
- Male
- Middle Aged
- Muscles
(physiopathology)
- Myasthenia Gravis
(immunology, physiopathology)
- Thymoma
(immunology, physiopathology)
- Thymus Neoplasms
(immunology, physiopathology)
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