Abstract | OBJECTIVE: METHODS: Serum PIIINP was measured using both assays in 33 patients with chronic hepatitis C and five healthy controls. Liver biopsies in chronic hepatitis C patients were scored using a previously described grading and staging system. RESULTS: Serum PIIINP was significantly elevated in chronic hepatitis C compared to controls using both the combined Col 1-3 and Col 1 (median 0.61 vs 0.33 U/ml, P=0.001) and Col 1 assays (median 6.5 vs 3.5 microg/l, P=0.006). Serum PIIINP measured by the combined assay was significantly related to liver fibrosis, periportal necrosis and histological activity index (P<0.05). The area under the curve for specificity and sensitivity in detecting advanced liver disease was only significant for the combined assay (P=0.017). Serum PIIINP measured by the Col 1 assay was not related to these indices of disease severity while serum ALT was only related to portal inflammation. CONCLUSION:
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Authors | K M Walsh, A Fletcher, R N MacSween, A J Morris |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 11
Issue 8
Pg. 827-31
(Aug 1999)
ISSN: 0954-691X [Print] England |
PMID | 10514112
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Procollagen
- Protein Precursors
- Reagent Kits, Diagnostic
- preprocollagen
- Collagen
- Alanine Transaminase
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Topics |
- Adult
- Alanine Transaminase
(blood)
- Biopsy
- Collagen
- Evaluation Studies as Topic
- Female
- Hepatitis C, Chronic
(blood)
- Humans
- Liver
(pathology)
- Male
- Procollagen
(blood)
- Protein Precursors
(blood)
- ROC Curve
- Radioimmunoassay
- Reagent Kits, Diagnostic
- Sensitivity and Specificity
- Severity of Illness Index
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