Normal collagen structure in the posterior ankle capsule in different types of clubfeet.

Abstract

In 21 clubfeet (17 children) of different types (idiopathic, spina bifida, syndromal), the authors analyzed modifications and crosslinks in collagen and their possible relations with clinical stiffness of clubfoot deformity, as measured by the Dimeglio/Bensahel method. In a biopsy of the capsule of the ankle joint, the number of hydroxylysine residues (mean +/- standard deviation; 27.1 +/- 3.4) and the number of pyridinium crosslinks per collagen molecule (0.41 +/- 0.12) were normal. This indicates normal processing of collagen molecules and normal alignment of collagen molecules within fibrils despite the variety of clubfeet, and even in scar tissue.

• Authors: J A van der Sluijs, J E Pruys
• Journal: Journal of pediatric orthopedics. Part B (J Pediatr Orthop B) Vol. 8 Issue 4 Pg. 261-3 (Oct 1999) ISSN: 1060-152X [Print] United States
• PMID: 10513360 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Collagen

Topics

• Ankle Joint (pathology, physiopathology)
• Child, Preschool
• Chromatography, High Pressure Liquid
• Clubfoot (diagnosis, pathology, physiopathology)
• Collagen (analysis, ultrastructure)
• Female
• Humans
• Infant
• Joint Capsule (pathology)
• Male
• Range of Motion, Articular
• Reference Values
• Sensitivity and Specificity
• Severity of Illness Index