Abstract |
Three neonates with chronic intrauterine meconium aspiration are reported. All had distinctive subpleural plate-infarcts of the lungs caused by meconium-induced vasoconstriction of peripheral preacinar arteries. These vessels showed plexogenic arteriopathy with medionecrosis and obliterative hyaline sclerosis. Organized thrombi and systemic-pulmonary arterial anastomoses were numerous. The infarcts contained inspissated meconium with a granulomatous reaction. In one case, lung rupture occurred, causing meconiumthorax and meconium embolism to hilar lymphatics and lymph nodes; this suggests that particulate meconium may enter the circulation. This fetus had rubella and probable acute twin-twin transfusion following the intrauterine death of the co-twin. The cause of the hypoxia that led to intrauterine passage of meconium in the other cases is unknown. Meconium-stained amniotic fluid was noted in only one case.
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Authors | M S Kearney |
Journal | Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
(Pediatr Dev Pathol)
Vol. 2
Issue 6
Pg. 544-51
( 1999)
ISSN: 1093-5266 [Print] United States |
PMID | 10508878
(Publication Type: Case Reports, Journal Article)
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Topics |
- Chronic Disease
- Diseases in Twins
- Fatal Outcome
- Female
- Humans
- Infant, Newborn
- Lung
(blood supply, pathology)
- Male
- Meconium Aspiration Syndrome
(complications, pathology)
- Pulmonary Embolism
(etiology, pathology)
- Respiratory Distress Syndrome, Newborn
(etiology, pathology)
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