Abstract | STUDY OBJECTIVES: METHODS: We used a convenience sample of children in a pediatric emergency department during the summer months of 1994 and 1995. Participants were pediatric patients less than 15 years of age with simple lacerations requiring suturing. RESULTS: Twenty-five patients were enrolled in the study. The mean age of the patients was 8.5 years (range, 3 to 13 years). Lacerations tended to be small, with a mean length of 2.2 cm (range, 1 to 8 cm). Plasma cocaine and benzoylecgonine levels were measured by means of high-performance liquid chromatography. The mean time for obtaining the plasma sample for cocaine analysis was 67.2+/-23.9 minutes (range, 28 to 130 minutes) after application of the viscous cocaine-containing TAC solution. Qualitative assay results, which were accurate to 50 ng/mL, were negative in all 25 patients for both plasma cocaine and benzoylecgonine. No child demonstrated any signs or symptoms suggestive of cocaine toxicity. CONCLUSION: In our study, application of viscous cocaine-containing TAC solutions to small lacerations did not produce clinically important cocaine absorption.
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Authors | R J Vinci, S Fish, M Mirochnick |
Journal | Annals of emergency medicine
(Ann Emerg Med)
Vol. 34
Issue 4 Pt 1
Pg. 498-502
(Oct 1999)
ISSN: 0196-0644 [Print] United States |
PMID | 10499951
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Combined
- Anesthetics, Local
- Tetracaine
- benzoylecgonine
- TEC solution
- Cocaine
- Epinephrine
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Topics |
- Adolescent
- Anesthetics, Combined
- Anesthetics, Local
- Child
- Child, Preschool
- Cocaine
(analogs & derivatives, blood)
- Epinephrine
- Female
- Humans
- Male
- Skin Absorption
- Tetracaine
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