Antibiotic residues in milk samples obtained from cows after treatment for papillomatous digital dermatitis.

Abstract

OBJECTIVE:

To determine whether there would be detectable antibiotic residues in milk obtained from dairy cattle with papillomatous digital dermatitis (PDD) after topical treatment with oxytetracycline.

DESIGN:

Randomized controlled clinical trial.

ANIMALS:

28 lactating Holstein cows with PDD.

PROCEDURE:

Cows were assigned to 2 treatment groups. Treatment 1 (n = 16) consisted of spraying of PDD lesions with 15 ml of a solution containing 100 mg of oxytetracycline/ml; lesions were sprayed twice daily for 7 days, using a garden sprayer. Treatment 2 (n = 12) consisted of a one-time application of a bandage that consisted of cotton soaked with 20 ml of a solution containing 100 mg of oxytetracycline/ml. Milk samples were obtained before and after treatment and assayed for tetracycline content by use of high-performance liquid chromatography and a commercially available tetracycline screening test.

RESULTS:

None of the cows in either treatment group had violative residues of oxytetracycline in milk samples.

CONCLUSIONS AND CLINICAL RELEVANCE:

Producers treating lactating cows that have PDD, via topical application of oxytetracycline solution at the concentrations reported in this study, have a low risk of causing violative antibiotic residues in milk.

• Authors: J S Britt, M C Carson, J D von Bredow, R J Condon
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 215 Issue 6 Pg. 833-6 (Sep 15 1999) ISSN: 0003-1488 [Print] United States
• PMID: 10496140 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Oxytetracycline

Topics

• Animals
• Anti-Bacterial Agents (analysis, therapeutic use)
• Cattle
• Cattle Diseases (drug therapy)
• Chromatography, High Pressure Liquid (veterinary)
• Dermatitis (drug therapy, veterinary)
• Drug Residues (analysis)
• Female
• Foot Diseases (drug therapy, veterinary)
• Hoof and Claw
• Milk (chemistry)
• Oxytetracycline (analysis, therapeutic use)
• Papilloma (drug therapy, veterinary)
• Treatment Outcome