Abstract | OBJECTIVE: DESIGN: Randomized controlled clinical trial. ANIMALS: 28 lactating Holstein cows with PDD. PROCEDURE: Cows were assigned to 2 treatment groups. Treatment 1 (n = 16) consisted of spraying of PDD lesions with 15 ml of a solution containing 100 mg of oxytetracycline/ml; lesions were sprayed twice daily for 7 days, using a garden sprayer. Treatment 2 (n = 12) consisted of a one-time application of a bandage that consisted of cotton soaked with 20 ml of a solution containing 100 mg of oxytetracycline/ml. Milk samples were obtained before and after treatment and assayed for tetracycline content by use of high-performance liquid chromatography and a commercially available tetracycline screening test. RESULTS: None of the cows in either treatment group had violative residues of oxytetracycline in milk samples. CONCLUSIONS AND CLINICAL RELEVANCE: Producers treating lactating cows that have PDD, via topical application of oxytetracycline solution at the concentrations reported in this study, have a low risk of causing violative antibiotic residues in milk.
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Authors | J S Britt, M C Carson, J D von Bredow, R J Condon |
Journal | Journal of the American Veterinary Medical Association
(J Am Vet Med Assoc)
Vol. 215
Issue 6
Pg. 833-6
(Sep 15 1999)
ISSN: 0003-1488 [Print] United States |
PMID | 10496140
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Oxytetracycline
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Topics |
- Animals
- Anti-Bacterial Agents
(analysis, therapeutic use)
- Cattle
- Cattle Diseases
(drug therapy)
- Chromatography, High Pressure Liquid
(veterinary)
- Dermatitis
(drug therapy, veterinary)
- Drug Residues
(analysis)
- Female
- Foot Diseases
(drug therapy, veterinary)
- Hoof and Claw
- Milk
(chemistry)
- Oxytetracycline
(analysis, therapeutic use)
- Papilloma
(drug therapy, veterinary)
- Treatment Outcome
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