Abstract |
We investigate a resampling method for bias correction in group sequential designs with censored survival data using logrank testing. The method draws nested bootstrap samples of different sizes from the observed data in order to mimic the large sample independent increment property of statistics resulting from sequential designs. The motivation for this problem came from the very positive results and early termination of a randomized clinical trial for nasopharyngeal cancer co-ordinated by the Southwest Oncology Group.
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Authors | M LeBlanc, J Crowley |
Journal | Statistics in medicine
(Stat Med)
Vol. 18
Issue 19
Pg. 2635-44
(Oct 15 1999)
ISSN: 0277-6715 [Print] England |
PMID | 10495461
(Publication Type: Journal Article)
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Copyright | Copyright 1999 John Wiley & Sons, Ltd. |
Chemical References |
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Cisplatin
- Fluorouracil
|
Topics |
- Antimetabolites, Antineoplastic
(therapeutic use)
- Antineoplastic Agents
(therapeutic use)
- Bias
- Cisplatin
(therapeutic use)
- Combined Modality Therapy
- Data Interpretation, Statistical
- Fluorouracil
(therapeutic use)
- Humans
- Nasopharyngeal Neoplasms
(drug therapy, mortality, radiotherapy)
- Randomized Controlled Trials as Topic
(methods)
- Research Design
- Survival Analysis
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