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Distribution of two HIV-1-resistant polymorphisms (SDF1-3'A and CCR2-64I) in East Asian and world populations and its implication in AIDS epidemiology.

Abstract
Chemokine receptor CCR2 and stromal-derived factor (SDF-1) are involved in HIV infection and AIDS symptom onset. Recent cohort studies showed that point mutations in these two genes, CCR2-64I and SDF1-3'A, can delay AIDS onset > or = 16 years after seroconversions. The protective effect of CCR2-64I is dominant, whereas that of SDF1-3'A is recessive. SDF1-3'A homozygotes also showed possible protection against HIV-1 infection. In this study, we surveyed the frequency distributions of the two alleles at both loci in world populations, with emphasis on those in east Asia. The CCR2-64I frequencies do not vary significantly in the different continents, having a range of 0.1-0.2 in most populations. A decreasing cline of the CCR2-64I frequency from north to south was observed in east Asia. In contrast, the distribution of SDF1-3'A in world populations varies substantially, and the highest frequency was observed in Oceanian populations. Moreover, an increasing cline of the SDF1-3'A frequency from north to south was observed in east Asia. The relative hazard values were computed to evaluate the risk of AIDS onset on the basis of two-locus genotypes in the east Asian and world populations.
AuthorsB Su, L Jin, F Hu, J Xiao, J Luo, D Lu, W Zhang, J Chu, R Du, Z Geng, X Qiu, J Xue, J Tan, S J O'Brien, R Chakraborty
JournalAmerican journal of human genetics (Am J Hum Genet) Vol. 65 Issue 4 Pg. 1047-53 (Oct 1999) ISSN: 0002-9297 [Print] United States
PMID10486323 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • CCR2 protein, human
  • CXCL12 protein, human
  • Chemokine CXCL12
  • Chemokines, CXC
  • Receptors, CCR2
  • Receptors, Chemokine
  • Receptors, Cytokine
Topics
  • Acquired Immunodeficiency Syndrome (epidemiology, genetics)
  • Age of Onset
  • Alleles
  • Chemokine CXCL12
  • Chemokines, CXC (genetics)
  • Asia, Eastern (epidemiology)
  • Gene Frequency (genetics)
  • Genes, Dominant (genetics)
  • Genes, Recessive (genetics)
  • Genetic Predisposition to Disease (genetics)
  • HIV-1 (physiology)
  • Humans
  • Pacific Islands (epidemiology)
  • Point Mutation (genetics)
  • Polymorphism, Genetic (genetics)
  • Polymorphism, Restriction Fragment Length
  • Prevalence
  • Proportional Hazards Models
  • Receptors, CCR2
  • Receptors, Chemokine
  • Receptors, Cytokine (genetics)
  • Time Factors

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