Abstract |
Chemokine receptor CCR2 and stromal-derived factor (SDF-1) are involved in HIV infection and AIDS symptom onset. Recent cohort studies showed that point mutations in these two genes, CCR2-64I and SDF1-3'A, can delay AIDS onset > or = 16 years after seroconversions. The protective effect of CCR2-64I is dominant, whereas that of SDF1-3'A is recessive. SDF1-3'A homozygotes also showed possible protection against HIV-1 infection. In this study, we surveyed the frequency distributions of the two alleles at both loci in world populations, with emphasis on those in east Asia. The CCR2-64I frequencies do not vary significantly in the different continents, having a range of 0.1-0.2 in most populations. A decreasing cline of the CCR2-64I frequency from north to south was observed in east Asia. In contrast, the distribution of SDF1-3'A in world populations varies substantially, and the highest frequency was observed in Oceanian populations. Moreover, an increasing cline of the SDF1-3'A frequency from north to south was observed in east Asia. The relative hazard values were computed to evaluate the risk of AIDS onset on the basis of two-locus genotypes in the east Asian and world populations.
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Authors | B Su, L Jin, F Hu, J Xiao, J Luo, D Lu, W Zhang, J Chu, R Du, Z Geng, X Qiu, J Xue, J Tan, S J O'Brien, R Chakraborty |
Journal | American journal of human genetics
(Am J Hum Genet)
Vol. 65
Issue 4
Pg. 1047-53
(Oct 1999)
ISSN: 0002-9297 [Print] United States |
PMID | 10486323
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- CCR2 protein, human
- CXCL12 protein, human
- Chemokine CXCL12
- Chemokines, CXC
- Receptors, CCR2
- Receptors, Chemokine
- Receptors, Cytokine
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Topics |
- Acquired Immunodeficiency Syndrome
(epidemiology, genetics)
- Age of Onset
- Alleles
- Chemokine CXCL12
- Chemokines, CXC
(genetics)
- Asia, Eastern
(epidemiology)
- Gene Frequency
(genetics)
- Genes, Dominant
(genetics)
- Genes, Recessive
(genetics)
- Genetic Predisposition to Disease
(genetics)
- HIV-1
(physiology)
- Humans
- Pacific Islands
(epidemiology)
- Point Mutation
(genetics)
- Polymorphism, Genetic
(genetics)
- Polymorphism, Restriction Fragment Length
- Prevalence
- Proportional Hazards Models
- Receptors, CCR2
- Receptors, Chemokine
- Receptors, Cytokine
(genetics)
- Time Factors
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