MR imaging of pancreatic lesions. Comparison of manganese-DPDP and gadolinium chelate.

Abstract

RATIONALE AND OBJECTIVES:

To compare manganese-DPDP-enhanced and gadolinium-DTPA-enhanced MR imaging in patients suspected of having pancreatic cancer.

METHODS:

Fifteen patients who underwent MR imaging for suspected pancreatic cancer and received gadolinium-DTPA took part in a clinical phase III trial in which the efficacy of manganese-DPDP for detection of pancreatic cancer was evaluated. T1-weighted gradient-echo (GRE) images with and without fat suppression were used. Signal-to-noise ratio and contrast-to-noise ratio were calculated before and after the administration of each contrast agent. Image quality was assessed using a four-step score; delineation of the normal pancreas was assessed by two readers in consensus.

RESULTS:

In terms of pancreatic signal-to-noise ratio, only gadolinium-DTPA-enhanced fat-suppressed and non-fat-suppressed GRE imaging showed a significant (P < 0.001) increase (72% and 61%, respectively). In the patients with a focal pancreatic lesion (n = 14), a significant increase in contrast-to-noise ratio was found only in manganese-DPDP-enhanced GRE imaging without (106%) and with (82%) fat saturation. Qualitative image analysis demonstrated a significant improvement of manganese-DPDP-enhanced fat-suppressed MR images in delineating the pancreatic parenchyma (P < 0.01) as well as pancreatic tumors (P < 0.01).

CONCLUSIONS:

T1-weighted manganese-DPDP-enhanced GRE imaging with fat saturation should be regarded as the most suitable combination for detecting a pancreatic lesion.

• Authors: S J Diehl, K J Lehmann, J Gaa, S McGill, V Hoffmann, M Georgi
• Journal: Investigative radiology (Invest Radiol) Vol. 34 Issue 9 Pg. 589-95 (Sep 1999) ISSN: 0020-9996 [Print] United States
• PMID: 10485075 (Publication Type: Clinical Trial, Clinical Trial, Phase III, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Contrast Media
• Pyridoxal Phosphate
• Edetic Acid
• Gadolinium DTPA
• N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid

Topics

• Adult
• Aged
• Carcinoma, Ductal, Breast (diagnosis)
• Chronic Disease
• Contrast Media
• Diagnosis, Differential
• Edetic Acid (analogs & derivatives)
• Female
• Gadolinium DTPA
• Humans
• Magnetic Resonance Imaging (methods)
• Male
• Middle Aged
• Pancreas (pathology)
• Pancreatic Diseases (diagnosis)
• Pancreatic Neoplasms (diagnosis)
• Pancreatitis (diagnosis)
• Pyridoxal Phosphate (analogs & derivatives)