Abstract |
The effects of histamine on the spatial memory deficits induced by MK-801 were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and intraperitoneal (i.p.) injection of histidine improved the spatial memory deficits induced by MK-801. Similar results were obtained with 2-thiazolylethylamine. In contrast, 4-methylhistamine showed no significant effect. Based on these observations, it seems likely that the protective effect of histamine on MK-801-induced spatial memory deficit is mediated by H(1)-receptors.
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Authors | Z Chen, Q Zhao, Y Sugimoto, Y Fujii, C Kamei |
Journal | Brain research
(Brain Res)
Vol. 839
Issue 1
Pg. 186-9
(Aug 21 1999)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 10482812
(Publication Type: Journal Article)
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Chemical References |
- Excitatory Amino Acid Antagonists
- Dizocilpine Maleate
- Histamine
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Topics |
- Analysis of Variance
- Animals
- Dizocilpine Maleate
(pharmacology)
- Excitatory Amino Acid Antagonists
(pharmacology)
- Histamine
(pharmacology)
- Injections, Intraperitoneal
- Injections, Intraventricular
- Male
- Maze Learning
(drug effects)
- Memory Disorders
(chemically induced, drug therapy)
- Psychomotor Performance
(drug effects)
- Rats
- Rats, Wistar
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