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Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats.

Abstract
The effects of histamine on the spatial memory deficits induced by MK-801 were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and intraperitoneal (i.p.) injection of histidine improved the spatial memory deficits induced by MK-801. Similar results were obtained with 2-thiazolylethylamine. In contrast, 4-methylhistamine showed no significant effect. Based on these observations, it seems likely that the protective effect of histamine on MK-801-induced spatial memory deficit is mediated by H(1)-receptors.
AuthorsZ Chen, Q Zhao, Y Sugimoto, Y Fujii, C Kamei
JournalBrain research (Brain Res) Vol. 839 Issue 1 Pg. 186-9 (Aug 21 1999) ISSN: 0006-8993 [Print] Netherlands
PMID10482812 (Publication Type: Journal Article)
Chemical References
  • Excitatory Amino Acid Antagonists
  • Dizocilpine Maleate
  • Histamine
Topics
  • Analysis of Variance
  • Animals
  • Dizocilpine Maleate (pharmacology)
  • Excitatory Amino Acid Antagonists (pharmacology)
  • Histamine (pharmacology)
  • Injections, Intraperitoneal
  • Injections, Intraventricular
  • Male
  • Maze Learning (drug effects)
  • Memory Disorders (chemically induced, drug therapy)
  • Psychomotor Performance (drug effects)
  • Rats
  • Rats, Wistar

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