[Lymphoepithelioma-like carcinoma of the lung].

Abstract

Lymphoepithelioma-like carcinoma of the lung was diagnosed in a 39-year-old Chinese woman. In situ hybridization of Epstein Barr virus-encoded small nuclear RNA 1 (EBER 1) detected strong EBER 1 signals in the nuclei of tumor cell specimens from the patient. After polymerase chain reaction (PCR) amplification, electrophoresis identified the IR-1 region in this tumor as a positive sharp band, closely resembling Raji cells (Burkitt's cell line). The uniform and intense presence of EBER 1 in the tumor nuclei and the PCR products of EBV DNA in the tumor demonstrated that a high copy number of EB virus genome existed in the tumor, and indicated involvement of the EB virus in the pathogenesis of lymphoepithelioma-like carcinoma of the lung.

• Authors: K Muraishi, S Kon, H Yosida, H Hamakawa, N Nakai, C Itoh, S Yamaoka, K Kasai
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 37 Issue 7 Pg. 565-70 (Jul 1999) ISSN: 1343-3490 [Print] Japan
• PMID: 10481464 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies, Viral

Topics

• Adult
• Antibodies, Viral (blood)
• Carcinoma, Squamous Cell (virology)
• Female
• Herpesvirus 4, Human (immunology, isolation & purification)
• Humans
• In Situ Hybridization
• Lung Neoplasms (virology)