Abstract | BACKGROUND: METHODS: Twelve females, aged 50-67 years, were included in the study with six of them receiving a 3-hour infusion of alprostadil at the standard dosage of 60 micrograms in 250 cc of physiological infusion for six consecutive days and the remaining six receiving placebo (250 cc of physiological infusion administered in the same manner). RESULTS: After infusion, blood flow, digitally measured by telethermography was increased only in patients treated with alprostadil. The number, frequency and severity of attacks recorded were reduced only in patients treated with alprostadil. No side effects were recorded during and after the infusion. CONCLUSION: In conclusion, alprostadil is effective in the management of Raynaud's phenomenon, due to scleroderma.
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Authors | S Bartolone, A Trifiletti, G De Nuzzo, R Scamardi, D Larosa, G Sottilotta, A Raffa, N Barbera |
Journal | Minerva cardioangiologica
(Minerva Cardioangiol)
Vol. 47
Issue 5
Pg. 137-43
(May 1999)
ISSN: 0026-4725 [Print] Italy |
PMID | 10479851
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Fibrinolytic Agents
- Placebos
- Alprostadil
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Topics |
- Alprostadil
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Fibrinolytic Agents
(therapeutic use)
- Humans
- Middle Aged
- Placebos
- Raynaud Disease
(complications, drug therapy)
- Scleroderma, Systemic
(complications, drug therapy)
- Treatment Outcome
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