HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Biomarkers of liver regeneration allow early prediction of hepatic recovery after acute necrosis.

Abstract
Acute toxic hepatic necrosis is common and may be fatal. Predicting clinical outcome may be aided by following serum markers that could indicate recovery or may signify massive (substantial) destruction of functional liver mass. Previously, in a published case of chloroform poisoning, we serially assayed serum biomarkers of hepatocellular necrosis (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase) and markers of hepatocellular regeneration (alpha-fetoprotein, retinol-binding protein, gamma-glutamyl transferase, and des-gamma-carboxyprothrombin). We noted a decline in necrotic markers and a synchronous elevation in regenerative markers, which could be suggestive of a favorable outcome in similar cases. We now report 6 Amanita mushroom poisonings with favorable outcome and 2 fatal acetaminophen poisonings in which the same markers were observed. Our results further support our hypothesis that a sustained decline in serum markers of hepatocyte necrosis with a concurrent elevation in regenerative markers could aid in prediction of favorable outcome in patients with acute liver injury.
AuthorsK D Horn, P Wax, S M Schneider, T G Martin, J S Nine, M A Moraca, M A Virji, P A Aronica, K N Rao
JournalAmerican journal of clinical pathology (Am J Clin Pathol) Vol. 112 Issue 3 Pg. 351-7 (Sep 1999) ISSN: 0002-9173 [Print] England
PMID10478140 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
Topics
  • Acute Disease
  • Adult
  • Biomarkers (blood)
  • Chemical and Drug Induced Liver Injury (blood, mortality, pathology)
  • Female
  • Humans
  • Liver Regeneration
  • Male
  • Middle Aged
  • Necrosis
  • Prognosis
  • Survival Rate
  • Time Factors
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: