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Response to plasma exchange and steroids as combined therapy for patients with thrombotic thrombocytopenic purpura.

Abstract
We describe our experience in the management of 11 consecutive patients with thrombotic thrombocytopenic purpura (TTP) treated with a combined therapy of plasma exchange (PE) and steroids. Nine patients (82%) achieved complete remission (CR) after a median of 6 rounds of PE (range 2-22). There were 3 early relapses managed in the same way as the initial episode. One patient relapsed 23 months after diagnosis achieving CR with standard therapy; another patient suffered several relapses, and splenectomy was performed after the last one. Three patients died, 2 of them with resistant disease 9 and 38 days after diagnosis, and the remaining one died due to AIDS-related complications while he was in CR. Eight patients are alive in CR with a median follow-up of 38 months (range 8-74). The combination of PE and steroids is a well-tolerated and effective treatment of TTP, but improvements in therapy are needed to manage refractory patients.
AuthorsJ de la Rubia, A López, F Arriaga, A R Cid, A I Vicente, M L Marty, M A Sanz
JournalActa haematologica (Acta Haematol) Vol. 102 Issue 1 Pg. 12-6 ( 1999) ISSN: 0001-5792 [Print] Switzerland
PMID10473882 (Publication Type: Journal Article)
Chemical References
  • Steroids
Topics
  • Adult
  • Aged
  • Combined Modality Therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Plasma Exchange
  • Purpura, Thrombotic Thrombocytopenic (mortality, therapy)
  • Recurrence
  • Retrospective Studies
  • Steroids (therapeutic use)
  • Survival Rate

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