Abstract |
Sex steroids accelerate bone maturation, but it is believed that estrogen action is needed for terminal epiphyseal fusion. In this study, we investigated the effects of a new estrogen-blocking agent, Faslodex ( ICI 182,780), on estrogen-accelerated skeletal maturation in immature mice. On day-of-life 2 through 8, mice pups received either estradiol (5 microg/100 g body weight), Faslodex (100 microg/100 g body weight), a combination of Faslodex + estradiol, or vehicle alone. Skeletal maturation was assessed with a scoring system based on the size and appearance of epiphyseal plates in the forepaw and the lumbar spine. Estradiol caused acceleration of bone maturation in our mouse model (p < 0.05). Faslodex blocked the effect of estrogen, such that the mice receiving Faslodex + estradiol did not vary significantly from controls. Faslodex may prove useful in the treatment of patients with diseases causing rapid skeletal maturation, such as precocious puberty.
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Authors | D F Gunther, A S Calikoglu, L E Underwood |
Journal | Pediatric research
(Pediatr Res)
Vol. 46
Issue 3
Pg. 269-73
(Sep 1999)
ISSN: 0031-3998 [Print] United States |
PMID | 10473040
(Publication Type: Journal Article)
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Chemical References |
- Estrogen Antagonists
- Estrogens
- Receptors, Estrogen
- Fulvestrant
- Estradiol
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Topics |
- Animals
- Animals, Newborn
- Bone Development
(drug effects, physiology)
- Estradiol
(analogs & derivatives, pharmacology)
- Estrogen Antagonists
(pharmacology)
- Estrogens
(physiology)
- Fulvestrant
- Mice
- Receptors, Estrogen
(antagonists & inhibitors, physiology)
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