Abstract | BACKGROUND: MATERIAL AND METHODS: RESULTS: There was a significant between-group difference in estrogen suppression during therapy. In comparison with baseline values, after four weeks of treatment the estradiol levels decreased by an average of 86.9% (95% CI, 70.5-94.2%) in the group treated with triptorelin alone and by 97.3% (95% CI, 94.1-98.8%; P = 0.0422) in the combination group; the respective figures for estrone were 48.5% (95% CI, 27.5-63.5%) and 70.4% (95% CI, 52.3-81.6%; P = 0.0007) and for estrone sulfate 56.7% (95% CI, 40-68.8%) and 80.5% (95% CI, 69.4-87.6%; P = 0.0055). No difference was observed between the groups in terms of gonadotropin suppression; both treatment modalities led to a slight but delayed decrease in SHBG levels. Three of the patients treated with triptorelin alone experienced tumor regression compared with four patients in the combination group. No appreciable side effects of the combination therapy were observed. CONCLUSION: The treatment of premenopausal patients with triptorelin plus 4-OHA is feasible and leads to a much greater inhibition of main circulating estrogens than treatment with the analog alone. Since the combination of a GnRH analog and an aromatase inhibitor might potentially enhance the anti- tumor efficacy of the analog alone owing to more favorable endocrine effects, such a therapeutic approach deserves more extensive evaluation in the clinical setting.
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Authors | L Celio, A Martinetti, L Ferrari, R Buzzoni, L Mariani, R Miceli, E Seregni, G Procopio, A Cassata, E Bombardieri, E Bajetta |
Journal | Anticancer research
(Anticancer Res)
1999 May-Jun
Vol. 19
Issue 3B
Pg. 2261-8
ISSN: 0250-7005 [Print] Greece |
PMID | 10472341
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Aromatase Inhibitors
- Receptors, Estrogen
- Receptors, Progesterone
- Sex Hormone-Binding Globulin
- Triptorelin Pamoate
- Estrone
- Androstenedione
- Estradiol
- formestane
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Topics |
- Adult
- Androstenedione
(administration & dosage, analogs & derivatives, therapeutic use)
- Antineoplastic Agents
(antagonists & inhibitors, therapeutic use)
- Antineoplastic Agents, Hormonal
(administration & dosage, therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Aromatase Inhibitors
- Breast Neoplasms
(blood, drug therapy, pathology, physiopathology)
- Estradiol
(blood)
- Estrone
(blood)
- Female
- Humans
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Staging
- Premenopause
- Receptors, Estrogen
(analysis)
- Receptors, Progesterone
(analysis)
- Sex Hormone-Binding Globulin
(analysis)
- Triptorelin Pamoate
(administration & dosage, therapeutic use)
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