Abstract | OBJECTIVE: DESIGN AND SETTING: Prospective, multicentre study. PATIENTS: A cohort of 172 HIV-infected patients with a CD4 cell count below 100x10(6) cells/l at the time of protease inhibitor introduction. MAIN OUTCOME MEASURES: Confirmed CMV retinitis and mortality, according to CD4 cell count, HIV load, and CMV viraemia. RESULTS: The cumulative incidence of CMV retinitis was 5% at 1 year and 6% at 2 years. Only a positive CMV polymerase chain reaction (PCR) test at therapy initiation was significantly associated with the development of disease (relative hazard, 4.41; 95% confidence interval, 2.12-8.93; P<0.00001). The 12-month Kaplan-Meier CMV retinitis event rate was 38% in patients who were CMV PCR-positive compared with 2% in those who were CMV PCR-negative (P<0.001). Mean CMV load was significantly higher in those individuals who went on to develop CMV retinitis (3700 versus 384 copies/ml, P = 0.002). Only 2% of patients remained CMV PCR-positive after 3 months of protease inhibitor therapy, and CMV viraemia was not associated with a worse therapy response or shorter survival. Transient CMV positivity without a higher risk of disease was observed in 7% of patients at the first month on therapy. CONCLUSIONS:
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Authors | J L Casado, J Arrizabalaga, M Montes, P Martí-Belda, C Tural, J Pinilla, C Gutierrez, J Portu, R Schuurman, K Aguirrebengoa |
Journal | AIDS (London, England)
(AIDS)
Vol. 13
Issue 12
Pg. 1497-502
(Aug 20 1999)
ISSN: 0269-9370 [Print] England |
PMID | 10465073
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA, Viral
- HIV Protease Inhibitors
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Topics |
- AIDS-Related Opportunistic Infections
(diagnosis, epidemiology, virology)
- CD4 Lymphocyte Count
- Cytomegalovirus
(isolation & purification, physiology)
- Cytomegalovirus Retinitis
(diagnosis, epidemiology, virology)
- DNA, Viral
(analysis)
- HIV Infections
(drug therapy)
- HIV Protease Inhibitors
(therapeutic use)
- HIV-1
(physiology)
- Humans
- Incidence
- Polymerase Chain Reaction
- Prospective Studies
- Risk Factors
- Viral Load
- Viremia
(virology)
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