Abstract |
The present study tested the effects of EUK-134, a synthetic superoxide dismutase/catalase mimetic, on several indices of oxidative stress and neuropathology produced in the rat limbic system as a result of seizure activity elicited by systemic kainic acid (KA) administration. Pretreatment of rats with EUK-134 did not modify the latency for or duration of KA-induced seizure activity. It did produce a highly significant reduction in increased protein nitration, activator protein-1- and NF-kappaB-binding activity, and spectrin proteolysis as well as in neuronal damage resulting from seizure activity in limbic structures. These results support the hypothesis that kainate-induced excitotoxicity is caused, at least in part, by the action of reactive oxygen species. Furthermore, they suggest that synthetic superoxide dismutase/catalase mimetics such as EUK-134 might be used to prevent excitotoxic neuronal injury.
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Authors | Y Rong, S R Doctrow, G Tocco, M Baudry |
Journal | Proceedings of the National Academy of Sciences of the United States of America
(Proc Natl Acad Sci U S A)
Vol. 96
Issue 17
Pg. 9897-902
(Aug 17 1999)
ISSN: 0027-8424 [Print] United States |
PMID | 10449791
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Reactive Oxygen Species
- Spectrin
- 3-nitrotyrosine
- Tyrosine
- Catalase
- Superoxide Dismutase
- Kainic Acid
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Topics |
- Animals
- Catalase
(metabolism)
- Electrophoresis, Polyacrylamide Gel
- Kainic Acid
(toxicity)
- Molecular Mimicry
- Oxidative Stress
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species
(metabolism)
- Spectrin
(metabolism)
- Superoxide Dismutase
(metabolism)
- Tyrosine
(analogs & derivatives, analysis)
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